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Methylated Vitamins

Methylated vitamins are a specialized category of vitamin supplements that have gained attention for their enhanced bioavailability and efficacy, particularly for certain groups of individuals. These vitamins are ‘methylated,’ meaning they have undergone a chemical process that adds a methyl group to their structure. This modification is crucial as it affects how vitamins are absorbed and utilized in the body.

The primary reason methylated vitamins are important lies in genetics. Some people have a genetic variation in the MTHFR gene, which can reduce their ability to convert certain vitamins, like folate (vitamin B9) and vitamin B12, into their active forms. This conversion is essential for processes such as DNA synthesis and repair, as well as homocysteine metabolism, which is linked to cardiovascular health. Methylated forms of these vitamins are already in their active state, bypassing the need for conversion, which makes them particularly beneficial for individuals with MTHFR gene variations.

The top 5 Methylated Vitamins

Product name Image Rating Pros Cons Best Price More information


Thorne Methyl-Guard Plus

Thorne Methyl-Guard Plus Methylated Vitamins
5 star review
  • Supports heart, blood vessel, brain, and bone health
  • Effective for maintaining healthy homocysteine levels
  • Contains active forms of key B vitamins for enhanced methylation
  • Higher price point compared to some other options
  • Requires taking multiple capsules daily
  • May not be suitable for those with specific dietary restrictions
Coming Soon!


Garden of Life Organic Multivitamin for Women

Garden of Life Organic Multivitamin for Women
  • Organic and formulated specifically for women
  • Incorporates a modest amount of whole foods
  • Vegan, vegetarian, dairy-free, gluten-free, soy-free, and non-GMO
  • Missing some essential nutrients like calcium and magnesium
  • Contains a long list of other ingredients
  • Two tablets per serving
Coming Soon!


Thorne Basic Nutrients 2/Day

Thorne Basic Nutrients 2/Day
  • NSF Certified for Sport
  • Vegan-friendly
  • Contains many key nutrients including the active form of folate and vitamin K2
  • Requires two capsules per serving
  • Might contain more B vitamins than needed for some individuals
  • Capsule size might be large for some users
Coming Soon!

PhytoMulti 120 tabs

PhytoMulti 120 tabs
  • Contains a blend of essential vitamins, minerals, and phytonutrients
  • Supports cellular health and healthy aging
  • Ideal for replenishing nutrients often lacking in modern diets
  • Higher cost
  • May contain ingredients not suitable for all dietary preferences.
  • The comprehensive formula might be more than needed for some users
Coming Soon!

Metagenics PhytoMulti with Iron

Metagenics PhytoMulti with Iron Methylated Vitamins
  • High-potency formula
  • Unique proprietary blend of phytonutrients
  • Gluten-free and non-GMO
  • Contains a long list of other ingredients
  • Tablet form may not be preferred by all users
  • Price may be higher compared to some other brands
Coming Soon!