Methylated vitamins are a specialized category of vitamin supplements that have gained attention for their enhanced bioavailability and efficacy, particularly for certain groups of individuals. These vitamins are 'methylated,' meaning they have undergone a chemical process that adds a methyl group to their structure. This modification is crucial as it affects how vitamins are absorbed and utilized in the body.

The primary reason methylated vitamins are important lies in genetics. Some people have a genetic variation in the MTHFR gene, which can reduce their ability to convert certain vitamins, like folate (vitamin B9) and vitamin B12, into their active forms. This conversion is essential for processes such as DNA synthesis and repair, as well as homocysteine metabolism, which is linked to cardiovascular health. Methylated forms of these vitamins are already in their active state, bypassing the need for conversion, which makes them particularly beneficial for individuals with MTHFR gene variations.

The top 5 Methylated Vitamins

Product name Image Rating Pros Cons Best Price More information

Thorne Methyl-Guard Plus

Thorne Methyl-Guard Plus Methylated Vitamins 5 star review
  • Supports heart, blood vessel, brain, and bone health
  • Effective for maintaining healthy homocysteine levels
  • Contains active forms of key B vitamins for enhanced methylation
  • Higher price point compared to some other options
  • Requires taking multiple capsules daily
  • May not be suitable for those with specific dietary restrictions
Coming Soon!

Garden of Life Organic Multivitamin for Women

Garden of Life Organic Multivitamin for Women
  • Organic and formulated specifically for women
  • Incorporates a modest amount of whole foods
  • Vegan, vegetarian, dairy-free, gluten-free, soy-free, and non-GMO
  • Missing some essential nutrients like calcium and magnesium
  • Contains a long list of other ingredients
  • Two tablets per serving
Coming Soon!

Thorne Basic Nutrients 2/Day

Thorne Basic Nutrients 2/Day
  • NSF Certified for Sport
  • Vegan-friendly
  • Contains many key nutrients including the active form of folate and vitamin K2
  • Requires two capsules per serving
  • Might contain more B vitamins than needed for some individuals
  • Capsule size might be large for some users
Coming Soon!

PhytoMulti 120 tabs

PhytoMulti 120 tabs
  • Contains a blend of essential vitamins, minerals, and phytonutrients
  • Supports cellular health and healthy aging
  • Ideal for replenishing nutrients often lacking in modern diets
  • Higher cost
  • May contain ingredients not suitable for all dietary preferences.
  • The comprehensive formula might be more than needed for some users
Coming Soon!

Metagenics PhytoMulti with Iron

Metagenics PhytoMulti with Iron Methylated Vitamins
  • High-potency formula
  • Unique proprietary blend of phytonutrients
  • Gluten-free and non-GMO
  • Contains a long list of other ingredients
  • Tablet form may not be preferred by all users
  • Price may be higher compared to some other brands
Coming Soon!

Additional Reading

Methylated vitamins, like methylfolate (the methylated form of folate) and methylcobalamin (the methylated form of vitamin B12), are used to support various health aspects. For example, they play a critical role in prenatal health, aiding in the proper development of the nervous system and reducing the risk of birth defects. They are also used to manage homocysteine levels, which, when elevated, can increase the risk of heart conditions. Additionally, these vitamins are integral to mental health, contributing to the synthesis of neurotransmitters and potentially aiding in the management of depression and anxiety.

Besides their specific benefits for people with MTHFR variations, methylated vitamins are often preferred for their general efficacy. The methylated forms are more readily absorbed and utilized by the body, making them a potentially better choice for boosting overall vitamin levels. This is particularly true for older adults, who may have a decreased ability to absorb certain vitamins.

It’s important to note that while methylated vitamins offer significant benefits, they may not be necessary for everyone. For individuals without MTHFR gene variations or specific health issues that require these forms, regular vitamins might suffice. Furthermore, excessive intake of certain vitamins, even in their methylated form, can lead to health issues. Therefore, it’s always recommended to consult with a healthcare professional before starting any new supplement regimen, especially if there are existing health concerns or if other medications are being taken.

In summary, methylated vitamins represent a significant advancement in the field of nutritional supplements, offering enhanced absorption and efficacy for individuals with specific genetic profiles or health needs. They underscore the importance of personalized nutrition and the growing understanding of how genetics can influence dietary requirements.

The History of Methylated Vitamins

Initially, vitamins were identified and used in their standard forms, with a focus on preventing and treating deficiency diseases. However, as research delved deeper into the genetic variations among individuals, it became apparent that not everyone metabolizes vitamins in the same way. This insight led to the development of methylated vitamins, specifically designed to be more readily absorbed and utilized by those with certain genetic polymorphisms.

Methylated vitamins have become increasingly popular as they are believed to offer enhanced bioavailability and efficacy, especially for those with specific genetic makeups that affect nutrient metabolism, such as mutations in the MTHFR gene. This personalized approach to nutrition, recognizing the unique genetic differences in nutrient metabolism, marks a significant shift in how we understand and use vitamins for optimal health.

Ingredients of Methylated Vitamins

Methylated vitamins are a special form of vitamins that have undergone a chemical process called methylation. This process makes them more easily absorbed and used by the body, especially for individuals with specific genetic mutations that affect vitamin metabolism. Common ingredients in methylated vitamin supplements include:
  • Methylcobalamin: A methylated form of Vitamin B12, used for better absorption.
  • Methylfolate: A methylated form of folate (Vitamin B9), crucial for those with MTHFR mutations.
  • Pyridoxal 5'-phosphate: A form of Vitamin B6, vital for various bodily functions.
  • Riboflavin 5'-phosphate: A form of Vitamin B2, involved in energy production.
These methylated forms are particularly beneficial for people with certain genetic profiles that make it hard to convert traditional forms of these vitamins into their active, usable forms.

Who should use Methylated Vitamins

Methylated vitamins are particularly beneficial for individuals with certain genetic variations that affect the metabolism of vitamins. These include mutations in the MTHFR gene, which can hinder the body's ability to convert folic acid and other B vitamins into their active forms. People with these genetic traits may find greater benefits from using methylated forms of vitamins, such as methylfolate (for folic acid) and methylcobalamin (for Vitamin B12), as these forms are already in a bioavailable state that the body can use directly. This makes methylated vitamins an excellent choice for those who have difficulty processing certain vitamins due to genetic factors.

Who shouldNOT use Methylated Vitamins

Individuals who should be cautious or might not need methylated vitamins typically include those who don't have genetic variations affecting vitamin metabolism, like MTHFR mutations. In such cases, regular vitamins might suffice, and there may be no added benefit from taking methylated forms. Additionally, people with certain health conditions or those taking specific medications should consult healthcare professionals before using these supplements. Methylated vitamins are more targeted for those with specific metabolic needs, and for the general population without these genetic considerations, standard vitamins are usually adequate.

Pros and Cons of Methylated Vitamins


  • Improved Absorption: Beneficial for individuals with genetic mutations like MTHFR, as they can absorb and utilize these vitamins more efficiently.
  • Enhanced Efficacy: Methylated forms are bioactive, meaning they can be directly used by the body without conversion.
  • Reduction in Side Effects: Can decrease the risk of unmetabolized folic acid accumulation, potentially reducing associated health risks.
  • Better Support for Specific Conditions: May offer more effective support for conditions like pregnancy, mood disorders, and cardiovascular health due to improved bioavailability.


  • Higher Cost: Methylated vitamins are often more expensive than non-methylated forms.
  • Not Necessary for Everyone: People without specific genetic mutations may not need methylated forms and can adequately process standard vitamins.
  • Potential Overmethylation: There’s a risk of too much methylation, which can disrupt normal bodily functions.
  • Limited Research: While there's growing interest, more comprehensive research is needed to fully understand the long-term effects and benefits.

Studies regarding the benefits of Methylated Vitamins

  • MTHFR Mutations and Homocysteine Levels: This study explores the relationship between MTHFR mutations, which can impair methylation, and elevated homocysteine levels, a risk factor for several health conditions including cardiovascular disease​​.
  • Methylated B Vitamins and Their Importance: Highlights the role of B vitamins in overall health and metabolism, and how methylated forms are more bioavailable and beneficial, especially for those with MTHFR gene mutations​​.
  • MTHFR and Methylated Vitamins for ADHD: Discusses the potential benefits of methylated vitamins for individuals with ADHD, particularly those with MTHFR mutations, and the importance of genetic testing in personalized health decisions​​.
  • Regular vs. Methylated B Complex: Compares regular and methylated B complex supplements, focusing on their importance for individuals with gene variations that affect methylation processes​​.

Frequently Asked Questions about Methylated Vitamins

What are methylated vitamins?

Methylated vitamins are vitamins that have undergone a process known as methylation, which involves the addition of a methyl group (CH3) to the vitamin molecule. This process makes the vitamins more readily usable by the body without requiring further conversion. The most commonly known methylated vitamins include methylfolate (a form of vitamin B9) and methylcobalamin (a form of vitamin B12).

Key Points about Methylated Vitamins:

  1. Bioavailability: Methylated vitamins are in their active form, meaning the body can use them directly. This is particularly beneficial for individuals who have genetic variations or mutations that affect their ability to convert standard vitamins into their active forms.
  2. Genetic Considerations: Some people have genetic mutations, such as MTHFR (methylenetetrahydrofolate reductase) mutations, which impair their ability to methylate vitamins. For these individuals, methylated vitamins can bypass the conversion step, ensuring they receive the necessary nutrients.
  3. Health Benefits:
    • Methylfolate (5-MTHF): Essential for DNA and RNA synthesis, red blood cell production, brain function, and reducing homocysteine levels.
    • Methylcobalamin: Vital for neurological function, DNA synthesis, red blood cell formation, and energy production.
  4. Dietary Sources and Supplements: While some methylated vitamins can be found in food (e.g., methylcobalamin in animal products), many people obtain them through supplements. This is especially important for those with dietary restrictions or genetic issues affecting vitamin conversion.
  5. Applications: Methylated vitamins are used to support various health conditions, including:
    • Cognitive function and mental health
    • Cardiovascular health by reducing homocysteine levels
    • Energy levels and reduction of fatigue
    • Prenatal health and prevention of neural tube defects
  6. Forms in Supplements: When choosing supplements, look for labels indicating methylated forms such as “methylfolate” or “methylcobalamin” to ensure you are getting the active form of the vitamin.


Methylated vitamins are crucial for individuals who have difficulty converting standard vitamin forms into their active states. They provide enhanced bioavailability and can help address specific health needs, particularly in people with certain genetic mutations or absorption issues.

Why are methylated vitamins important?

Methylated vitamins are crucial for individuals with genetic variations that impair their ability to convert standard forms of vitamins into their active forms. For example, people with the MTHFR (methylenetetrahydrofolate reductase) gene mutation may have difficulty converting folic acid into its active form, methylfolate. Using methylated vitamins bypasses these conversion steps, ensuring adequate nutrient availability for important bodily functions like DNA synthesis, energy production, and detoxification.

Who should consider taking methylated vitamins?

Individuals with certain genetic mutations (such as MTHFR), those with absorption issues, and people with conditions that impair the conversion of vitamins to their active forms may benefit from methylated vitamins. Additionally, anyone experiencing symptoms of vitamin deficiencies despite adequate intake may consider using methylated forms. Genetic testing and consultation with a healthcare provider can help determine if methylated vitamins are appropriate.

What are the benefits of methylated folate (methylfolate)?

Methylated folate is crucial for:

  • DNA and RNA synthesis and repair
  • Red blood cell production
  • Brain function and mental health
  • Reducing homocysteine levels, which is important for heart health
  • Supporting fetal development during pregnancy to prevent neural tube defects

What are the benefits of methylated B12 (methylcobalamin)?

  • Methylated B12 supports:
    • Red blood cell formation
    • Neurological function and maintenance of the nervous system
    • DNA synthesis
    • Energy production and reduction of fatigue
    • Conversion of homocysteine to methionine, supporting cardiovascular health

Are there any side effects of taking methylated vitamins?

Methylated vitamins are generally well-tolerated, but some individuals may experience side effects such as:

  • Headaches
  • Digestive issues (nausea, diarrhea)
  • Insomnia or jitteriness (usually from high doses)
  • Skin reactions (rashes)

It is essential to start with low doses and gradually increase if necessary, under the guidance of a healthcare provider.

How do I know if I have an MTHFR mutation?

Genetic testing is the only way to confirm the presence of an MTHFR mutation. This can be done through a healthcare provider or direct-to-consumer genetic testing services. The test typically involves a simple blood or saliva sample. Consulting with a healthcare provider about testing is recommended, especially if there are symptoms of nutrient deficiencies or a family history of such mutations.

Can I get enough methylated vitamins from my diet?

While some methylated vitamins are available in the diet, such as methylcobalamin found in animal products, most dietary sources provide vitamins in their non-methylated forms. Those with genetic mutations or absorption issues may struggle to get adequate amounts from diet alone. In such cases, supplementation with methylated vitamins can be beneficial.

What is the difference between methylfolate and folic acid?

Folic acid is a synthetic form of vitamin B9 used in supplements and fortified foods, which needs to be converted into its active form, methylfolate, by the body. Methylfolate is the bioactive form that the body can use directly without conversion. For individuals with MTHFR mutations, methylfolate is more effective because it bypasses the conversion step that may be impaired.

How should I choose a methylated vitamin supplement?

When choosing a methylated vitamin supplement, consider the following:

  • Quality: Look for supplements from reputable brands that provide third-party testing for purity and potency.
  • Form: Ensure the supplement contains the methylated form of the vitamin, such as methylfolate or methylcobalamin.
  • Dosage: Start with a lower dose and adjust as needed, based on symptoms and guidance from a healthcare provider.
  • Additional Nutrients: Some supplements combine methylated vitamins with other supportive nutrients, like other B vitamins, to enhance overall benefit.
  • Certifications: Check for certifications such as GMP (Good Manufacturing Practices) to ensure the supplement meets high-quality standards.