Qunol Ultra CoQ10 100mg Softgels

CoQ10, or Coenzyme Q10, is a naturally occurring compound found in every cell of the body. It plays a critical role in the production of energy within cells, specifically in the mitochondria, the energy-producing structures in cells. CoQ10 is vital for the creation of adenosine triphosphate (ATP), which the body uses for energy transfer and various other critical functions. As such, CoQ10 is essential for maintaining the health and functioning of virtually all cells, tissues, and organs in the body.

The top 8 CoQ10 supplements

Product name Image Rating Pros Cons Best Price More information

TOP PICK
Qunol Ultra CoQ10 100mg Softgels

Qunol Ultra CoQ10 100mg Softgels
  • Water and fat-soluble for better absorption
  • Beneficial for statin drug users
  • Free of milk and milk by-products
  • Contains additional ingredients like polysorbate 80 and gelatin
  • Some users report a strong taste
  • Softgel form may not be preferred by all
Coming Soon!

BUDGET PICK
Purely Holistic CoQ10 100mg

Purely Holistic CoQ10 100mg
  • Contains BioPerine for better absorption
  • Non-GMO and free from artificial fillers
  • Provides a 4-month supply
  • Some users reported stomach upset
  • Pills might be large for some users
  • Contains rice flour as a filler
Coming Soon!

VEGAN FRIENDLY
NOW Supplements, CoQ10

NOW Supplements, CoQ10
  • Fast-acting.
  • Contains 2% salicylic acid.
  • Reduces pimple redness and size quickly.
  • Expensive.
  • Small tube for the price
  • Increased Sun Sensitivity
  • Can be drying for some
Coming Soon!

ALLERGEN FRIENDLY
Jarrow Formulas QH-Absorb 100 mg

Jarrow Formulas QH-Absorb 100 mg
  • Contains the reduced form (Ubiquinol) which may be more effective for some users
  • Promises better absorption
  • No wheat, gluten, soybeans, dairy, egg, fish/shellfish, or peanuts/tree nuts
  • Some users reported digestive discomfort
  • Ubiquinol can be more expensive than Ubiquinone
  • Softgel capsule contains gelatin
Coming Soon!

Doctor’s Best High Absorption CoQ10

Doctor's Best High Absorption CoQ10 4 and a half star review
  • Uses BioPerine for improved absorption
  • Gluten-free and soy-free
  • Available in various dosage options
  • Contains extra ingredients like rice powder
  • Some users may prefer a pure liquid softgel
  • Not suitable for vegetarians since it's in a gelatin capsule
Coming Soon!

Nature Made CoQ10 200mg

Nature Made CoQ10 200mg
  • Vegetarian/Vegan
  • Contains Vitamin E and Selenium which aid in absorption
  • GMP quality assured
  • Some users reported stomach upset
  • Contains soy
  • Capsule form might not be the most bioavailable option
Coming Soon!

Sports Research CoQ10 supplements

Sports Research CoQ10 supplements
  • Contains organic virgin coconut oil for better absorption
  • Non-GMO and gluten-free
  • Comes in a softgel form
  • Contains gelatin, so not suitable for vegetarians
  • Some users report a strong aftertaste
  • Pricey for some users
Coming Soon!

Life Extension Super Ubiquinol CoQ10 supplements

Life Extension Super Ubiquinol CoQ10 supplements
  • Contains the Ubiquinol form
  • Enhanced delivery system for better absorption
  • Non-GMO
  • Some users didn't see notable benefits
  • Higher price point compared to Ubiquinone forms
  • Contains beeswax, so may not be suitable for vegans
Coming Soon!

Additional Reading

The human body naturally produces CoQ10, and it can also be obtained through certain foods like meats, fish, and whole grains. However, its levels may decrease with age, certain health conditions, or as a side effect of some medications, especially statins, which are used to lower cholesterol. A decline in CoQ10 levels can affect the body's ability to produce energy and protect against oxidative damage.

This is where CoQ10 supplements come into play. These supplements are often used to address potential deficiencies and have been explored for a range of potential health benefits. One of the most commonly cited benefits of CoQ10 supplementation is its potential to support heart health. Some research suggests that CoQ10 can help lower blood pressure, reduce the risk of adverse cardiovascular events in those with heart diseases, and improve symptoms in individuals with congestive heart failure.

Another significant area of interest is CoQ10's potential as an antioxidant. The body is constantly under attack from free radicals, which are unstable molecules that can cause cellular damage. Antioxidants like CoQ10 can neutralize these free radicals, protecting cells from oxidative stress. This antioxidative property is believed to confer various benefits, from slowing down the aging process to reducing the risk of certain chronic diseases.

CoQ10 supplements have also been examined for their potential in improving exercise performance, reducing headaches and migraines, improving skin health, and even supporting fertility. Some preliminary studies have even looked into CoQ10's role in neurodegenerative diseases, given its importance in cellular energy production.

The History of CoQ10 supplements

CoQ10, also known as ubiquinone and ubiquinol, was first discovered by American scientists in 1957. This fat-soluble substance plays a crucial role in the electron transport chain of aerobic cellular respiration, producing energy in the form of ATP, and acts as a powerful antioxidant.

Dr. Karl Folkers and Dr. Svend Aage Mortensen are two notable figures in the history of CoQ10 research. Dr. Folkers, known for his work in the biochemical study of disease conditions and the use of nutritional supplements, was instrumental in determining the structure of CoQ10 in 1958. He also conducted significant research into the effects of CoQ10 on heart failure, suspecting that a deficiency in CoQ10 could lead to energy starvation in heart muscle cells.

Dr. Mortensen, a Danish cardiologist and researcher, led the Q-Symbio study, a landmark clinical trial completed in 2014. This study provided crucial evidence supporting the use of CoQ10 as an adjunctive treatment for chronic heart failure. The trial focused on the patients’ disease symptoms, biomarkers, and long-term outcomes, such as hospitalization rates and mortality rates.

CoQ10 is essential for human growth and development, and the body's production of CoQ10 peaks in a person’s 20s and then decreases with age. Additionally, Dr. Folkers discovered that statin medications, used to inhibit cholesterol biosynthesis, also inhibit the biosynthesis of CoQ10. This led to the realization that CoQ10 deficiency could be a side effect of statin use, and supplementation might be necessary for some individuals.

In summary, the development and understanding of CoQ10 supplements have been significantly shaped by the work of Dr. Folkers and Dr. Mortensen, among others. Their research has highlighted the importance of CoQ10 in cardiovascular health and the potential need for supplementation, especially in older adults and those taking statin medications​

Ingredients of CoQ10 supplements

The ingredients of CoQ10 supplements can vary depending on the brand and specific product. However, the main ingredient is always coenzyme Q10 (CoQ10), which can be in two forms:

  • Ubiquinone This is the oxidized form of CoQ10 and is generally less expensive.
  • Ubiquinol This is the reduced form of CoQ10 and is considered more bioavailable, meaning it's more readily absorbed by the body. Some studies suggest it may also be more effective.




In addition to CoQ10, other common ingredients in CoQ10 supplements include:
  • Fillers and binders These help to give the supplement its shape and consistency. Examples include rice bran oil, gelatin, and vegetable glycerin.
  • Antioxidants These help to protect the CoQ10 from degradation. Examples include vitamin E and alpha-lipoic acid.
  • Excipients These are inactive ingredients that help with manufacturing, such as flavors, colors, and sweeteners.

Who should use CoQ10 supplements

Individuals with specific health conditions:

  • Heart failure: Some studies suggest CoQ10 may improve symptoms and exercise capacity in certain cases. However, it's not a replacement for prescribed treatments.
  • Statin users: Statin medications can lower CoQ10 levels. Some studies suggest supplementation might be beneficial, but consult your doctor for personalized advice.
  • Mitochondrial diseases: These rare genetic conditions affect energy production in cells, and CoQ10 deficiency is sometimes a factor. Supplementation may be prescribed under medical supervision.

Others potentially exploring CoQ10:

  • Adults over 40: CoQ10 production naturally declines with age, leading some to consider supplementation. However, research on its general benefits for healthy individuals is inconclusive.
  • Athletes: Preliminary studies suggest potential benefits for exercise performance and recovery, but more research is needed. Always consult a sports nutritionist or doctor before using supplements for athletic purposes.

What CoQ10 supplements is NOT intended for

1. People with certain health conditions:

  • Pregnant or breastfeeding women: Safety data on CoQ10 supplementation for pregnant or breastfeeding women is limited. It's best to avoid it unless explicitly recommended by a healthcare professional.
  • Individuals with blood clotting issues: There's potential for CoQ10 to interfere with blood thinners, potentially increasing the risk of bleeding. Always consult your doctor if you take blood thinners.
  • People with diabetes: CoQ10 may affect blood sugar levels. If you have diabetes, monitor your blood sugar closely and discuss CoQ10 with your doctor before taking it.

2. People taking certain medications:

  • Blood thinners (e.g., warfarin): As mentioned above, CoQ10 could interact with blood thinners, altering their effectiveness.
  • Chemotherapy drugs: Some studies suggest CoQ10 might interfere with the effectiveness of certain chemotherapy drugs. Consult your oncologist before using CoQ10 during cancer treatment.
  • Thyroid medications: Limited evidence suggests CoQ10 might affect the absorption of thyroid medication. Discuss this with your doctor if you take thyroid medication.

3. People with specific allergies:

  • Individuals with allergies to soybeans or sesame: Some CoQ10 supplements contain these ingredients, so check the label carefully if you have such allergies.

4. Children:

  • The safety and efficacy of CoQ10 for children haven't been fully established. Avoid giving it to children without discussing it with their doctor first.

5. People undergoing surgery:

  • Some sources suggest CoQ10 might affect blood sugar control during and after surgery. Discuss this with your doctor if you're planning surgery.

Pros and Cons of CoQ10 supplements

Pros

  • Supports Heart Health: CoQ10 is known for its benefits in heart health, particularly for those with heart failure or on statin medications.
  • Energy Production: It plays a crucial role in the production of energy within cells, particularly beneficial for organs with high energy demands like the heart and liver.
  • Antioxidant Properties: CoQ10 acts as an antioxidant, protecting cells from damage caused by harmful molecules.
  • May Benefit Statin Users: Statin medications can reduce CoQ10 levels in the body, so supplementation may be beneficial.
  • Anti-aging Effects: Its antioxidant properties may contribute to improved skin health and a reduction in the signs of aging.
  • Supports Fertility: May improve fertility, particularly in older women, by protecting eggs from oxidative damage.
  • Cognitive Health: CoQ10 might have a protective effect on cognitive health by reducing oxidative damage in the brain.
  • Improved Exercise Performance: Some studies suggest it may help reduce fatigue and improve exercise performance.

Cons

  • Potential Interactions with Medications: CoQ10 can interact with certain medications, including blood thinners and chemotherapy drugs.
  • Side Effects: Some people may experience mild side effects such as digestive discomfort, nausea, and headaches.
  • Varied Absorption Rates: Absorption of CoQ10 can vary between individuals, affecting its efficacy.
  • Cost: High-quality CoQ10 supplements can be relatively expensive.
  • Cost: High-quality CoQ10 supplements can be relatively expensive.
  • Not a Substitute for Treatment: While beneficial, CoQ10 is not a replacement for medical treatment of chronic diseases.
  • Research Is Ongoing: While benefits are reported, more research is needed for conclusive evidence in some areas.
  • Not for Everyone: People with certain health conditions should consult a healthcare provider before taking CoQ10.

Studies regarding the efficacy of CoQ10 supplements

Title: "Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges"
Summary: This study delves into the effectiveness and safety of CoQ10, addressing the challenges related to its formulation. It emphasizes the clinical importance of CoQ10 in various therapeutic areas and discusses ways to improve its delivery in the body​​.

Title: "Coenzyme Q10"
Summary: This review covers the role of CoQ10 in cardiovascular health, detailing its benefits and potential as a therapeutic agent for various heart-related conditions​​.

Title: "Recent Developments in the Role of Coenzyme Q10 for Coronary Heart Disease: a Systematic Review"
Summary: This systematic review focuses on recent developments in the use of CoQ10 for treating coronary heart disease, highlighting its potential benefits in this area​​.

Title: "Administration"
Summary: The study explores the different forms and strengths of CoQ10 supplements available, ranging from 30 to 600 mg per unit, and their ease of accessibility. It also discusses the potential benefits of CoQ10 supplementation in various health conditions, including statin-related myalgias, Peyronie disease, migraine prevention, and primary CoQ10 deficiency​​.

Frequently Asked Questions about CoQ10 supplements

What is CoQ10?

Coenzyme Q10 (CoQ10) is a naturally occurring antioxidant found in every cell of the body. It plays a critical role in the production of energy within the mitochondria, the powerhouse of the cell. CoQ10 is essential for the proper functioning of various organs and chemical reactions in the body. It helps produce adenosine triphosphate (ATP), which is involved in energy transfer within cells. CoQ10 also has antioxidant properties, protecting cells from damage caused by free radicals.

What are the benefits of taking CoQ10 supplements?

CoQ10 supplements offer several potential benefits, including:

  • Improved Heart Health: CoQ10 can help manage heart failure, reduce blood pressure, and improve overall heart function.
  • Enhanced Energy Levels: By supporting mitochondrial function, CoQ10 may boost energy and reduce fatigue.
  • Antioxidant Protection: CoQ10 helps neutralize free radicals, reducing oxidative stress and potentially slowing aging and disease progression.
  • Improved Exercise Performance: CoQ10 may enhance physical performance by reducing oxidative stress in muscles and improving mitochondrial functions.
  • Migraine Prevention: Some studies suggest CoQ10 can reduce the frequency and severity of migraines.
  • Skin Health: CoQ10 can help reduce wrinkles and protect skin from damage caused by UV rays.

Who should consider taking CoQ10 supplements?

CoQ10 supplements may be beneficial for:

  • Individuals with Heart Conditions: Such as heart failure, hypertension, or those who have had a heart attack.
  • People with Chronic Fatigue: Or those experiencing general fatigue and low energy levels.
  • Patients on Statin Medications: Statins can reduce CoQ10 levels in the body, so supplementation might be necessary.
  • Athletes: To potentially improve performance and recovery.
  • Individuals with Migraines: To reduce the frequency and severity of attacks.
  • Aging Adults: Natural CoQ10 levels decline with age, so supplements can help maintain optimal levels.

How much CoQ10 should I take daily?

The recommended daily dosage of CoQ10 varies based on individual needs and health conditions:

  • General Health and Maintenance: 90-200 mg per day.
  • Heart Health: 100-300 mg per day, divided into two or three doses.
  • Migraine Prevention: 300 mg per day.
  • Statin Users: 30-100 mg per day. Higher doses (up to 600 mg) might be prescribed for specific conditions under medical supervision. It’s important to consult with a healthcare provider before starting CoQ10 supplementation.

Are there any side effects of CoQ10 supplements?

CoQ10 is generally well-tolerated, but some people may experience side effects, including:

  • Digestive Issues: Such as nausea, vomiting, diarrhea, and stomach upset.
  • Insomnia: CoQ10 can sometimes cause difficulty sleeping if taken in the evening.
  • Rashes: Allergic reactions, though rare, can occur.
  • Headaches and Dizziness: In some individuals. To minimize side effects, it’s recommended to take CoQ10 with meals and start with a lower dose, gradually increasing it as tolerated.

Can CoQ10 interact with medications?

Yes, CoQ10 can interact with certain medications, including:

  • Blood Thinners (e.g., Warfarin): CoQ10 might reduce the effectiveness of these medications, increasing the risk of blood clots.
  • Blood Pressure Medications: CoQ10 can lower blood pressure, so combining it with antihypertensive drugs may cause blood pressure to drop too low.
  • Chemotherapy Drugs: CoQ10 can interfere with some chemotherapy medications. It’s crucial to consult with a healthcare provider before starting CoQ10, especially if you are on any medication.

How long does it take for CoQ10 supplements to work?

The time it takes for CoQ10 supplements to show noticeable effects can vary depending on the individual and the condition being treated. Some people may start to feel more energetic within a few days to weeks. For heart health benefits or migraine prevention, it might take several weeks to months of consistent use to observe significant improvements. Patience and consistency are key when taking CoQ10 supplements.

Is there a difference between Ubiquinone and Ubiquinol forms of CoQ10?

Yes, CoQ10 supplements come in two forms: ubiquinone and ubiquinol.

  • Ubiquinone: The oxidized form of CoQ10, which needs to be converted into ubiquinol in the body to be used effectively.
  • Ubiquinol: The reduced, active form of CoQ10, which is more readily absorbed and utilized by the body. Ubiquinol is often recommended for older adults or individuals with impaired absorption, as it may provide better bioavailability and efficacy.

Can CoQ10 improve fertility?

CoQ10 may have positive effects on fertility for both men and women:

  • Men: CoQ10 can improve sperm quality, motility, and count by reducing oxidative stress and supporting mitochondrial function.
  • Women: CoQ10 can enhance egg quality and ovarian response, particularly in older women or those undergoing fertility treatments. While more research is needed, CoQ10 supplementation is considered a promising option for individuals facing fertility challenges.

Are there natural food sources of CoQ10?

Yes, CoQ10 is found in several foods, though in smaller amounts compared to supplements. Rich dietary sources of CoQ10 include:

  • Meat: Especially organ meats like liver and kidney.
  • Fish: Such as sardines, mackerel, and salmon.
  • Vegetables: Spinach, broccoli, and cauliflower.
  • Legumes: Soybeans, peanuts, and lentils.
  • Nuts and Seeds: Sesame seeds and pistachios. While incorporating these foods into your diet can help increase CoQ10 levels, supplements are often necessary to achieve therapeutic dosages.